Ponatinix (Ponatinib 15mg)

Ponatinix (Ponatinib 15mg) is the best generic kinase inhibitor indicated for the:

1.Treatment of adult patients with chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) or Ph+ ALL for whom no other tyrosine kinase inhibitor (TKI) therapy is indicated.

2.Treatment of adult patients with T315I-positive CML (chronic phase, accelerated phase, or blast phase) or T315I-positive Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL).

Limitations of Use: Ponatinix (Ponatinib) is not indicated and is not recommended for the treatment of patients with newly diagnosed chronic phase CML.

Ponatinib Price & Ponatinib Cost:

Ponatinib (Iclusig) price in United States is about $17,000 per 30 Tablets. Generic Ponatinib price in India online pharmacy is only 8% of Panatinib cost in US.

Ponatinib dosage

1.Recommended dose: 45 mg taken orally once daily with or without food

2.Hepatic Impairment: 30 mg orally once daily

3.Modify or interrupt dosing for hematologic and non-hematologic toxicity

Ponatinib Side Effects

Blood clots or blockage in your blood vessels (arteries and veins). Blood clots or blockage in your blood vessels may lead to heart attack, stroke, or death. A blood clot or blockage in your blood vessels can prevent proper blood flow to your heart, brain, bowels (intestines), legs, eyes, and other parts of your body. You may need emergency surgery or treatment in a hospital. Get medical help right away if you get any of the following symptoms:

chest pain or pressure  pain in your arms, legs, back, neck or jaw shortness of breath  numbness or weakness on one side of leg swelling trouble talking headache dizziness your body severe stomach area pain decreased vision or loss of vision

Blood clots or blockage in your blood vessels can happen in people with or without risk factors for heart and blood vessel disease, including people 50 years of age or younger. The most common risk factors for these problems are a history of high blood pressure (hypertension), high levels of fat in the blood (hyperlipidemia), and heart disease. Blood clots or blockages in your blood vessels happen more often in people as they get older, and in people with a past history of decreased blood flow, high blood pressure, diabetes, or high levels of fats in the blood.

Heart problems. Ponatinib can cause heart problems, including heart failure which can be serious and may lead to death. Heart failure means your heart does not pump blood well enough. Ponatinib can also cause irregular slow or fast heartbeats and heart attack. Your healthcare provider will check you for heart problems during your treatment with Ponatinib. Get medical help right away if you get any of the following symptoms: shortness of breath, chest pain, fast or irregular heartbeats, dizziness, or feel faint.

Liver problems. Ponatinib can cause liver problems, including liver failure, which can be severe and may lead to death. Your healthcare provider will do blood tests before and during your treatment with Ponatinib to check for liver problems. Get medical help right away if you get any of these symptoms of liver problems during treatment:

yellowing of your skin or the white part of your eyes (jaundice)

dark “tea-colored” urine  sleepiness loss of appetite bleeding or bruising

Ponatinib PI

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