XIGDUO XR is a combination of dapagliflozin, an SGLT2 inhibitor, and metformin, a biguanide, that assists in regulating blood sugar levels in adults with type 2 diabetes mellitus, when accompanied by a proper diet and exercise regimen. Furthermore, dapagliflozin is prescribed to reduce the probability of hospitalization due to heart failure in adults with type 2 diabetes mellitus and pre-existing cardiovascular disease or multiple cardiovascular risk factors. It also reduces the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure (NYHA class II-IV) who have a reduced ejection fraction, and mitigates the risk of prolonged eGFR decline, end-stage kidney disease, cardiovascular death, and hospitalization for heart failure in adults with chronic kidney disease who are at risk of progression.
Xigduo xr dosage
• Renal function should be evaluated prior to starting treatment and periodically thereafter. • Assess the patient's volume status and correct any depletion before initiating treatment. • Determine the starting dose based on the patient's current treatment and individualize it accordingly. • Administer the medication orally once daily in the morning with food. • To improve glycemic control, the recommended starting dose for patients not already taking dapagliflozin is 5 mg once daily. • The recommended dose for indications related to heart failure and chronic kidney disease is 10 mg once daily. • The daily dose of dapagliflozin should not exceed 10 mg in combination with 2,000 mg of metformin HCl extended-release. • Consult the Full Prescribing Information for dosing in patients with renal impairment. • XIGDUO XR may require discontinuation before or during iodinated contrast imaging procedures.
xigduo xr 10 1000 price in india
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side effects of xigduo xr 10 1000
XIGDUO XR includes metformin, which may lead to a rare but severe medical condition called lactic acidosis, characterized by a buildup of acid in the blood that can be fatal. Seek immediate medical attention if you experience any of the following symptoms that may indicate lactic acidosis:
• Feeling cold in your hands or feet • Dizziness or lightheadedness • Slow or irregular heartbeat • Extreme weakness or fatigue • Unusual muscle pain • Breathing difficulties • Unusual sleepiness or prolonged sleep • Stomach pains, nausea, or vomiting
Most people who have developed lactic acidosis while taking metformin had underlying medical conditions or other factors that, when combined with metformin use, contributed to the development of the condition. It is essential to inform your healthcare provider if you have any of the following conditions as they may increase your risk of developing lactic acidosis with XIGDUO XR:
• Severe kidney problems or kidney damage resulting from certain x-ray tests that involve injectable dye • Liver problems • Regular alcohol consumption or binge drinking • Dehydration due to fever, vomiting, diarrhea, or excessive sweating without sufficient fluid intake • Recent surgery • Worsening symptoms of congestive heart failure, such as shortness of breath or increased fluid retention and swelling in the legs • A recent heart attack, severe infection, or stroke • Age 65 years or older
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