Hernix (Neratinib) is a generic kinase inhibitor indicated for the extended adjuvant treatment of adult patients with early stage HER2-overexpressed/amplified breast cancer, to follow adjuvant trastuzumab-based therapy.
Generic Neratinib Cost & Price:
Generic Neratinib’s price is only 15% compare to previous
DOSAGE AND ADMINISTRATION
1. Antidiarrheal prophylaxis: Initiate loperamide with the first dose of Neratinib and continue during first 2 cycles (56 days) of treatment. Instruct patients to maintain 1-2 bowel movements per day and on how to use antidiarrheal treatment regimens
2.Recommended dose: 240 mg (6 tablets) given orally once daily with food, continuously for one year.
3.Dose interruptions and/or dose reductions are recommended based on individual safety and tolerability.
3.Hepatic Impairment: Reduce starting dose to 80 mg in patients with severe hepatic impairment.
Neratinib Side Effects：
Diarrhea. Diarrhea is a common side effect of NERATINIB , but it can also be severe. You may lose too much body salts and fluids, and get dehydrated. Your healthcare provider should prescribe the medicine loperamide for you during your first 2 months (56 days) of NERATINIB and then as needed. To help prevent or reduce diarrhea:
o You should start taking loperamide with your first dose of NERATINIB. o Keep taking loperamide during the first 2 months (56 days) of NERATINIB treatment and then as needed. Your
healthcare provider will tell you exactly how much and how often to take loperamide. o Always take loperamide exactly as your healthcare provider tells you. o While taking loperamide, you and your healthcare provider should try to keep the number of bowel movements
that you have at 1 or 2 bowel movements each day.
o Tell your healthcare provider if you have more than 2 bowel movements in 1 day, or you have diarrhea that does not go away.
o Call your healthcare provider right away, as instructed, if you have severe diarrhea or if you have diarrhea along with weakness, dizziness, or fever.
o Your healthcare provider may also need to give you other medicines to manage diarrhea if loperamide does not work well enough.
o After2months(56days) of treatment with NERATINIB ,follow your health care provider’s instructions about taking loperamide as needed to control diarrhea.
Your healthcare provider may change your dose of NERATINIB , temporarily stop or completely stop NERATINIB if needed to manage your diarrhea.
For more Prescribing information，please check with our customer support for the → “FDA Prescribing Information”.
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