Zecyte 500 mg, which is also known as Abiraterone 500, is a medication that inhibits CYP17. It is intended to be used in conjunction with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer (CRPC) or metastatic high-risk castration-sensitive prostate cancer (CSPC).
Abiraterone acetate Dosage
To treat metastatic castration-resistant prostate cancer, patients should take 1,000mg of Abiraterone orally once a day along with 5mg of prednisone taken orally twice daily. For metastatic castration-sensitive prostate cancer, patients should take 1,000mg of Abiraterone orally once a day with 5mg of prednisone taken orally once a day. It is crucial that patients taking Abiraterone also receive a gonadotropin-releasing hormone (GnRH) analog at the same time or have undergone bilateral orchiectomy.
Abiraterone tablets should be taken once daily as a single dose, ideally on an empty stomach. Patients should avoid eating food for 2 hours before and 1 hour after taking Abiraterone, and they should swallow the tablets whole with water, without crushing or chewing them.
For certain patients, dose adjustments may be necessary. The starting dose of Abiraterone should be reduced to 250mg once daily for those with moderate hepatic impairment (Child-Pugh Class B) at baseline. If patients experience hepatotoxicity during treatment, Abiraterone should be stopped until they recover, and then retreatment may begin at a lower dose. If severe hepatotoxicity occurs, Abiraterone should be discontinued altogether.
Abiraterone 500 mg price
Abiraterone acetate 500mg is priced at only 10% of the cost in other countries when purchased in India.
Abiraterone side effect
Abiraterone may result in severe side effects, such as high blood pressure (hypertension), fluid retention (edema), and low potassium levels in the blood (hypokalemia). If you experience any of the following symptoms, you must notify your healthcare provider immediately:
Discontinuing prednisone, getting an infection, or experiencing stress may result in adrenal problems. Liver problems are also a possible risk and may cause changes in liver function blood tests. Your healthcare provider will conduct liver function blood tests before and during Abiraterone treatment. Liver failure can be fatal; therefore, it is critical to inform your healthcare provider of any of the following changes:
Common side effects of Abiraterone include joint pain or swelling, leg or feet swelling, weakness, cough, vomiting, hot flashes, diarrhea, high blood pressure, shortness of breath, urinary tract infection, anemia (low red blood cells), low blood potassium levels (hypokalemia), high blood sugar levels (hyperglycemia), high blood cholesterol or triglycerides, and abnormal blood test results. If any side effects persist or cause concern, you should contact your healthcare provider.
This list does not cover all the potential side effects of Abiraterone. Please consult your healthcare provider or pharmacist for more information.
For more information on how to prescribe Abiraterone, please refer to the "FDA Prescribing Information."
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