Obetohep 5 is one of the best generic obeticholic acid available in India for treating primary biliary cholangitis (PBC) in adults who are either intolerant to or have not had a sufficient response to ursodeoxycholic acid (UDCA). This therapy can be administered alone or in combination with UDCA.
Obeticholic Acid Dosage
During the first 90 days of treatment with Obeticholic, the recommended dose is 5 mg per day for patients with non-cirrhotic or compensated Child-Pugh Class A conditions, and 5 mg per week for those with Child-Pugh Class B or C conditions or a history of decompensation.
If the patient has not achieved a satisfactory decrease in ALP and/or total bilirubin after this initial period, and is tolerating the medication, the dosage may be adjusted. Patients with non-cirrhotic or compensated Child-Pugh Class A conditions may be prescribed 10 mg per day, while those with Child-Pugh Class B or C conditions or a previous decompensation event may start with 5 mg twice per week (at least three days apart) and titrate up to 10 mg twice per week based on their response and ability to tolerate the medication.
The maximum dosage of Obeticholic is 10 mg per day for patients with non-cirrhotic or compensated Child-Pugh Class A conditions, and 10 mg twice per week (at least three days apart) for those with Child-Pugh Class B or C conditions or a history of decompensation. It is important to reassess the patient's Child-Pugh classification before making any adjustments to their dosage. Decompensation events include new or worsening jaundice, spontaneous bacterial peritonitis, and gastroesophageal variceal bleeding.
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Obeticholic Acid Side Effects：
It is common for Obeticholic Acid to cause itching (pruritus) as a side effect, which may sometimes become severe and affect large areas of the body. Severe itching can result in discomfort, disrupted sleep, and difficulty carrying out daily activities. In such cases, medical attention and treatment are necessary. If you experience severe itching or notice that your itching is getting worse, promptly inform your healthcare provider.
Another possible side effect of Obeticholic Acid is a decrease in high-density lipoprotein cholesterol (HDL-C), also known as "good" cholesterol. Your healthcare provider will monitor your cholesterol levels while you are receiving treatment with Obeticholic Acid.
To learn more about the prescribing guidelines, please refer to the "Prescribing Information" provided by our supporter.
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