Tipanat (Tipiracil 8.19 mg/ Trifluridine 20 mg), a nucleoside metabolic inhibitor, is combined with tipiracil, a thymidine phosphorylase inhibitor, to create a medication indicated for the treatment of certain conditions in adult patients. These conditions include metastatic colorectal cancer in patients who have already received treatment with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if they have RAS wild-type, an anti-EGFR therapy. The medication is also indicated for the treatment of metastatic gastric or gastroesophageal junction adenocarcinoma in patients who have previously undergone at least two lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, HER2/neu-targeted therapy.
Trifluridine Tipiracil price
Trifluridine cost in other countries is about $4,200, Trifluridine Tipiracil price in India is only 5%.
35 mg/m2 /dose orally twice daily with food on Days 1 through 5 and Days 8 through 12 of each 28-day cycle.
Trifluridine/Tipiracil side effects
TIPANAT can result in severe and potentially life-threatening side effects, such as low blood counts. This medication may decrease your white blood cells, red blood cells, and platelets, making you more susceptible to serious infections that can be fatal. Your healthcare provider will conduct blood tests before starting TIPANAT, on day 15 of treatment, and as needed to monitor your blood cell counts. If your white blood cell or platelet counts are low, your healthcare provider may reduce your TIPANAT dosage or discontinue treatment.
During treatment with TIPANAT, contact your healthcare provider immediately if you experience signs of infection, such as fever, chills, or body aches. Inform your healthcare provider of all medical conditions, including kidney or liver problems, and pregnancy or plans to become pregnant. TIPANAT can harm unborn babies, and women of childbearing age must use effective birth control while taking this medication and for six months following the last dose. Males must use a condom during sex with female partners who can become pregnant while on TIPANAT and for three months after their last dose. Breastfeeding is not recommended during TIPANAT treatment and for one day after the final dose.
Inform your healthcare provider of all prescription and over-the-counter medications, vitamins, and herbal supplements you are taking. The most common side effects of TIPANAT are fatigue, weakness, nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever. If you experience severe or persistent nausea, vomiting, or diarrhea, notify your doctor. This is not a comprehensive list of all TIPANAT side effects, and for more information, speak with your healthcare provider. If you experience side effects while taking TIPANAT, contact your doctor for medical advice.
|Don't take the drug without consulting a qualified doctor or physician
|Follow the doctor's advice
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