Xapavir (Dolutegravir 50 ), an HIV-1 integrase strand transfer inhibitor (INSTI) prescribed as part of a comprehensive antiretroviral regimen. Xapavir is specifically indicated for the treatment of HIV-1 infection in the following populations:
Adults: It is suitable for both treatment-naïve individuals and those with prior treatment experience. Xapavir is a recommended option for adults with varying treatment histories.
Pediatric Patients: Xapavir is approved for use in pediatric patients who are either treatment-naïve or have previous treatment experience but are INSTI-naïve. The minimum age requirement is at least 4 weeks, and the minimum weight requirement is at least 3 kg.
Xapavir, with its potent INSTI activity, serves as an essential component in combination with other antiretroviral agents to effectively manage HIV-1 infection in both adults and pediatric patients.
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Treatment-naïve or treatment-experienced INSTI-naïve or virologically suppressed adults switching to dolutegravir + rilpivirine: Take 50mg once daily.
Treatment-naïve or treatment-experienced INSTI-naïve adults when used alongside specific UDP-UGT1A or CYP3A inducers: Take 50mg twice daily.
INSTI-experienced adults with certain INSTI-associated resistance substitutions or clinically suspected INSTI resistance: Take 50mg twice daily.
Please refer to the complete product labeling. For infants below 4 weeks of age, weighing less than 3kg, or those with INSTI-experienced with documented or clinically suspected resistance to other INSTIs (such as raltegravir, elvitegravir), the appropriate dosage has not been established.
For children aged 4 weeks or older:
Weight between 14kg and less than 20kg: Take 40mg once daily.
Weight of 20kg or more: Take 50mg once daily.
If dolutegravir is used concomitantly with specific UGT1A or CYP3A inducers, the weight-based dose should be increased to twice daily.
It is important to note that the above dosing information is a general guideline and individualized dosing may vary. It is essential to consult with a healthcare professional for accurate dosage instructions tailored to the patient's specific needs and medical condition.
Dolutegravir 50 mg side effects:
Allergic reactions. Call your healthcare provider right away if you develop a rash with DOLUTEGRAVIR or DOLUTEGRAVIR. Stop taking DOLUTEGRAVIR or DOLUTEGRAVIR and get medical help right away if you develop a rash with any of the following signs or symptoms: o fever o generally ill feeling o tiredness o muscle or joint aches o blisters or sores in mouth o blisters or peeling of the skin o redness or swelling of the eyes o swelling of the mouth, face, lips, or tongue o problems breathing • Liver problems. People with a history of hepatitis B or C virus may have an increased risk of developing new or worsening changes in certain liver tests during treatment with DOLUTEGRAVIR or DOLUTEGRAVIR. Liver problems, including liver failure, have also happened in people without a history of liver disease or other risk factors. Your healthcare provider may do blood tests to check your liver. Call your healthcare provider right away if you develop any of the following signs or symptoms of liver problems: o your skin or the white part of your eyes turns yellow (jaundice) o dark or “tea-colored” urine o light-colored stools (bowel movements) o nausea or vomiting o loss of appetite o pain, aching, or tenderness on the right side of your stomach area • Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV-1 medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Tell your healthcare provider right away if you start having new symptoms after you start taking DOLUTEGRAVIR or DOLUTEGRAVIR.
• The most common side effects of DOLUTEGRAVIR include: o trouble sleeping o tiredness o headache.
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